Stem Cells Restore Toddler's Congenital Hearing Loss

In a potentially revolutionary treatment, a two years old toddler born deaf has had her hearing restored after receiving stem cells from her banked umbilical cord blood. (Reported in ABC News)

Madeline Connor at age 1 year old was completely deaf in the right ear and had severe hearing loss on the left. Normally hearing aids or cochlear implant would have been the only options.

However, in January 2012 at the age of 2 years old, Madeline underwent a "simple" experiment whereby stem cells were infused into her damaged inner ear. The stem cells were derived from umbilical cord blood that was banked at the time of her delivery at the Memorial Hermann-Texas Medical Center.

Over the next 6 months, there has been dramatic improvement in her hearing. She is also now talking for the first time.

Madeline also is not the only child who has undergone this revolutionary stem cell treatment. Apparently, there are ten other children who are being followed after undergoing similar stem cell infusion derived from banked cord blood.

It must be stressed that though Madeline's progress is quite amazing, it is still too early to say if this is a "bona fide" treatment for congenital hearing loss.

• Will the improvement continue and more importantly, last over years to decades?
• Will it work for other children?
• What is the expected hearing improvement with stem cell infusion?
• Will it treat ALL forms of nerve-damaged hearing loss?
• Does it have to be stem cells derived from cord blood or are stem cells derived from other sources possible (i.e., skin)?
• Can adults with non-congential hearing loss also benefit?

I eagerly await the outcome of this FDA approved trial which hopefully will be published at some point in the near future.

I also eagerly await the protocol used to obtain and infuse the stem cells. I suspect the infusion of stem cells is similar to that done when steroids are infused into the ear for sudden hearing loss as shown in this video below. However, this is just a guess of mine.

Source:

Cord Blood Stem Cells Restore Toddler's Hearing. ABC News 7/11/12

Hearing Loss Reversed by Teeth

When a patient is totally deaf in just one ear (normal hearing on the other side), there are only a few options to help.

• BAHA - Bone Anchored Hearing Aid
• CROS Hearing Aid - Stands for Contralateral Routing Of Signals.

With BAHA, it does require surgery given the hearing aid is literally mounted on a post that is directly drilled into the skull on the deaf ear side. Total cost about $10,000.

With CROS, two hearing aids are required; one on the deaf hear which picks up sound, and another on the good ear where the sound is transmitted to. Total cost about $2,500.

Well, for many folks, having surgery is not palatable and wearing two hearing aids when one ear is perfectly good is also not acceptable.

There's now a third option called SoundBite (cost about $6,800).

With SoundBite, a hearing aid is placed in the deaf ear to pick up sound which is than wirelessly transmitted to a mini-retainer like device placed around the back molars. This special retainer vibrates the teeth which in turn vibrates the skull which sends sound waves to the good ear allowing a patient to hear.

And preliminary results show that patients like it the best among the three options.

However, nothing is all good...

The disadvantage with the SoundBite is battery life. The ear piece battery only lasts about 12-15 hours and the teeth retainer piece about 8 hours. Also, the teeth retainer needs to be fitted by a dentist.

Also, not everybody is a candidate for SoundBite. In order to quality, a patient must have:

1) Good teeth and gums
2) Deaf in only one side with normal hearing on the other. A comprehensive hearing test is required obviously.

Source:

Using Teeth to Help Restore Hearing in One Ear. WSJ 7/10/12

Rush Limbaugh Has a Cochlear Implant

Infamous conservative talk show host, Rush Limbaugh, suffered from a rare hearing disorder called Autoimmune Inner Ear Disease.

This rare inner ear disease is principally characterized by progressive bilateral fluctuating hearing loss and occurs when the body's own immune system starts to attack the hearing mechanism of the ear... much like rheumatoid arthritis is when the body's immune system attacks the joints. Just as with any other auto-immune disorder, it is mainly treated with repeated courses of prednisone.

However, if the hearing gets poor enough, the patient may become essentially deaf for which even hearing aids are ineffective which is what happened to Mr. Limbaugh.

To restore his hearing, he underwent surgical placement of a cochlear implant at the House Ear Institute in Los Angeles. It is truly a "bionic" ear in that a computer hears the world around him and directly stimulates the hearing nerve bypassing the cochlea.

Here's a transcript of him describing what it's like.

Source:
Questions on the Host's Hearing. March 18, 2011
Rush Limbaugh's Cochlear Implant Surgery A Success. Audiology Online. 1/3/2002.