Generic Singulair Expected in August 2012

Why August 2012? That's when the patent for singulair, an allergy and asthma medication, goes off-patent. Generic versions of singulair should be expected soon after the patent expires.

For those who don't know... generic versions of medications are much cheaper than brand name medications, but contain the same active ingredient. Here's a list of a few brand name medications relevant in the ENT world with generic names in parentheses.

Flonase (fluticasone)
Prilosec (omeprazole)
Prevacid (lansoprazole)
Claritin (loratidine)
Zyrtec (cetirizine)
Benadryl (diphenhydramine)

Nasal Hair Protective Against Asthma in Patients with Allergies?

Researchers in Turkey found that there is an association between nasal hair density and risk of asthma developing in patients with seasonal rhinitis patients. No joke... They published their findings in the International Archives of Allergy and Immunology in March 2011.

The rate of asthma found in patients with little or no nasal hair was 44.7% whereas only 16.7% of patients with a dense forest of nasal hair had asthma.

They hypothesize that increased nasal hair improves allergen filtration thereby preventing the allergens from irritating the airway. The assumption here being that allergen irritation of the airway can potentially cause asthma.

IF this is true (and that's a big if)... patients with allergies should be encouraged to grow nice thick nasal hair to prevent future asthma!

Read the research abstract here!

Reference:
Does Nasal Hair (Vibrissae) Density Affect the Risk of Developing Asthma in Patients with Seasonal Rhinitis? Int Arch Allergy Immunol. 2011 Mar 30;156(1):75-80

Video of Exercise Induced Vocal Cord Dysfunction

Vocal cord dysfunction (also known as paradoxical vocal cord movement) is a condition where the true vocal cords (TVC) do not move the way they are supposed to. Normally, the vocal cords move apart (abduct) when breathing and come together (adduct) when talking.

Vocal cord dysfunction is when the vocal cords adduct (come together) when breathing resulting in shortness of breath and at its worst, complete airway obstruction resulting in stridor known as laryngospasm.

The video shown here shows a patient with exercise induced vocal cord dysfunction (her breathing attacks occur only with exercise). The first part of the video shows this patient at rest breathing normally. The latter half of the video shows the patient after exercising and suffering from a mild case of vocal cord dysfunction.

Note how the vocal cords come together briefly with inhalation causing the patient to perceive inadequate breathing.

Treatment depends on finding the trigger and addressing the trigger whether it be allergy, reflux, etc. If all possible triggers have been ruled-out, neuropathic medications like neurontin and elavil can be tried. If the side effects are unacceptable or the medications just do not work, botox injections to the vocal cords can be performed.

Speech therapy can also be pursued in order to learn coping mechanisms to help a patient deal with an attack when it happens.

Hypoallergenic Cats and Dogs

CBS news published a story on hypoallergenic pets on their website here.

The story did report that pricey pets that claim to be easy on allergy sufferers are probably more hype than true, but than did go on to list dogs and cats that are purportedly hypoallergenic.

The claim for hypoallergenicity is based on hair/fur/dander length or quantity... mainly the shorter or smaller the amount, the less allergenic. However, there are other reasons why hypoallergenic pets are NOT hypoallergenic. These include a pet's saliva and skin which contain the same protein that trigger allergic reactions.

Also, many dog allergy sufferers also have weed, tree, and grass allergies. If your hypoallergenic dog likes to roll in the grass and weed, they are getting that all over them and bringing it into the house and to you. So even if you are not allergic to the dog, you probably are allergic to what's on the dog.

Read the CBS story here.

Possible Novel Cure for Cat Allergy?

A research team in Canada has developed a possible cure for patients suffering from cat allergy using a novel type of allergy shot called peptide immunotherapy.

To understand the significance of this development, one needs to understand how traditional allergy shots are made. Currently, allergy companies purify a protein called Fel d1 from cats and make a vial out of it. This purification process is like removing the corn kernels from a cornstalk to put into a can to sell at the supermarket.

Peptide immunotherapy as described in this new research is like making the "essence" of the corn kernel in the lab. For this cat vaccine, the key molecule created is a 7 amino acid long peptide sequence.

The benefits of this novel treatment is the lack of side-effects when the shots are administered (meaning, no waiting around after the shot)... and only four to eight shots per year are required (rather than the weekly injections with current allergy shots).

The optimal dose to use is currently being determined in phase three clinical trials.

Reference:
Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy. J Allergy Clin Immunol. 2011 Jan;127(1):89-97, 97.e1-14.